| 英文名稱 | YKL-05-099 |
|---|---|
| 中文名稱 | YKL-05-099 |
| CAS號 | 1936529-65-5 |
| 分子式 | C32H34ClN7O3 |
| 分子量 | 600.11 |
| 外觀 | White to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
| 英文名稱 | YKL-05-099 |
|---|---|
| 中文名稱 | YKL-05-099 |
| CAS號 | 1936529-65-5 |
| 分子式 | C32H34ClN7O3 |
| 分子量 | 600.11 |
| 外觀 | White to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM).
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.
PMID: 27224444 PMCID: PMC4992440 DOI: 10.1021/acschembio.6b00217