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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
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規(guī)格

庫存

目錄價

會員專享價

數(shù)量

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基本信息

英文名稱	Tolcapone \| Ro 40-7592
中文名稱	托卡朋
CAS號	134308-13-7
分子式	C14H11NO5
分子量	273.24
外觀	Light yellow to yellow powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773?nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

相關(guān)文獻(xiàn)

Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone.

PMID: 9681662 DOI: 10.1007/s002280050448

PMID: 20150427 PMCID: PMC2865316 DOI: 10.1074/jbc.M109.080390

PMID: 28429453 PMCID: PMC5463066 DOI: 10.1002/cam4.1065

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托卡朋

Tolcapone | Ro 40-7592

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