| 英文名稱 | IMP-1088 |
|---|---|
| 中文名稱 | IMP-1088 |
| CAS號 | 2059148-82-0 |
| 分子式 | C25H29F2N5O |
| 分子量 | 453.53 |
| 外觀 | Colorless to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
| 英文名稱 | IMP-1088 |
|---|---|
| 中文名稱 | IMP-1088 |
| CAS號 | 2059148-82-0 |
| 分子式 | C25H29F2N5O |
| 分子量 | 453.53 |
| 外觀 | Colorless to light yellow powder |
| 儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection.