| 英文名稱 | Osilodrostat (LCI699) |
|---|---|
| 中文名稱 | 奧西卓司他 |
| CAS號 | 928134-65-0 |
| 分子式 | C13H10FN3 |
| 分子量 | 227.24 |
| 外觀 | White to yellow pwder |
| 儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
| 英文名稱 | Osilodrostat (LCI699) |
|---|---|
| 中文名稱 | 奧西卓司他 |
| CAS號 | 928134-65-0 |
| 分子式 | C13H10FN3 |
| 分子量 | 227.24 |
| 外觀 | White to yellow pwder |
| 儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Osilodrostat, also known as LCI699, is a potent inhibitor of 11β-hydroxylase, the enzyme which catalyzes the final step of cortisol synthesis. LCI699 may thus be a potential new treatment for all forms of Cushing's syndrome. Current evidence indicates that the novel aldosterone inhibitor LCI699 is an effective and well-tolerated antihypertensive agent that lowers plasma aldosterone concentration and produces a mild ACTH-stimulated cortisol response suppressive effect.