| 英文名稱 | Neratinib (HKI-272) |
|---|---|
| 中文名稱 | 來那替尼 |
| CAS號(hào) | 698387-09-6 |
| 分子式 | C30H29ClN6O3 |
| 分子量 | 557.04 |
| 外觀 | Pale yellow to white solid |
| 儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
| 英文名稱 | Neratinib (HKI-272) |
|---|---|
| 中文名稱 | 來那替尼 |
| CAS號(hào) | 698387-09-6 |
| 分子式 | C30H29ClN6O3 |
| 分子量 | 557.04 |
| 外觀 | Pale yellow to white solid |
| 儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.